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From Discrete to Continuous

As the number of loci increases, a discrete ratio converges to the bell curve of a continuous trait.

1 1 : 2 : 1

Where Do You Fall?

Additive alleles nudge by fractions of a millimeter. A single dominant mutation shifts by tens of centimeters.

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population mean

Genotype Effects: AA / AB / BB

Three patterns of how alleles influence traits — and why additive dominates.

Orthogonalized Dominance

When you adjust volume and bass boost simultaneously, how do you know which one changed the sound? Orthogonalization separates the additive signal (allele dosage: 0→1→2) from the dominance signal (heterozygote deviation: 0→1→0) so each can be measured independently.

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chaek.org · Human Genetics Ch.14–15