GWAS tests millions of SNPs simultaneously. With a standard threshold of p < 0.05, most "hits" would be noise. Adjust the parameters to see how many false positives you'd expect.
Each dot is one SNP. The x-axis is chromosomal position. The y-axis is −log₁₀(p-value). Click peaks to learn about associated loci.
A quantile-quantile plot compares observed p-values to what we'd expect by chance. Deviation only in the tail = real signal. Early deviation = systematic inflation (confounding).
A polygenic score (PGS) sums up thousands of small genetic effects. Toggle risk alleles on or off to see your cumulative score — and corresponding disease risk for dilated cardiomyopathy (DCM).
DCM study: 14,256 cases, 1,199,156 controls, 80 loci identified.