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Composite Architecture

Disease risk comes from two very different kinds of variants. Toggle each category to see how rare high-impact mutations and common low-effect GWAS variants together shape the genetic landscape.

Risk Accumulation

Alzheimer's disease risk is not binary — it accumulates as genetic factors stack up. Add risk factors one by one to watch amyloid burden rise and cognition decline.

Three Diseases, One Principle

DCM, Alzheimer's, and ASD each have radically different genetic inputs — but those inputs funnel into shared biological pathways. Toggle between diseases to see genetic heterogeneity converging.

chaek.org · Human Genetics Ch.19